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  • Scientific Publications

    Studies

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    We have selected a variety of studies here. Many more can be found by searching PubMed.

    Ozone therapy in veterinary medicine: A review

    March 2020 | Italy

    Arthritis

    Ozone Therapy

    Ozone (O3) is a triatomic form of oxygen. As O3rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O3/O2is used in medicine. ATP is widely available for cellular activity. O3can be ad...

    Comparative evaluation of the effect of Ozone therapy and Photodynamic therapy in non-surgical management of Chronic periodontitis

    Oct 2020 | Italy

    Cancer

    Ozone Therapy

    A split-mouth longitudinal study was conducted to compare and evaluate the effect of ozonated water and photodynamic therapy (PDT) in nonsurgical management of chronic periodontitis, along with mechanical debridement procedure...

    Ozone therapy in COVID-19: A narrative review

    October 2020 | Italy

    Arthritis

    Rectal Insufflation

    The performance of horses undergoing regular intense exercise is adversely affected by oxidative stress. Thus, it is important to increase antioxidant production in horses in order to reduce oxidative stress. Ozonated autohemotherapy (OAHT) rep...

    Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro

    October 2020 | Italy

    Arthritis

    Rectal Insufflation

    In clinical practice, administration of low ozone (O3) dosages is a complementary therapy for many diseases, due to the capability of O3 to elicit an antioxidant response through the NuclearFactor Erythroid 2-Related Factor 2 (Nrf2)-dependent p...

    Aqueous ozone therapy improves the standard treatment of leishmaniasis lesions in animals leading to local and systemic alterations.

    October 2020 | Brazil

    Arthritis

    Rectal Insufflation

    The current treatment of leishmaniasis presents some problems, such as cell toxicity, parenteral route, and time of treatment. Ozone emerges as an option to accelerate the standard treatment due to the immunomodulatory, antioxidant, and wound h...

    Intrauterine therapy with ozone reduces subclinical endometritis and improves reproductive performance in postpartum dairy cows managed in pasture-based systems

    September 2020 | Ecuador

    Arthritis

    New postpartum strategies have been developed in dairy cows to ameliorate uterine health and reproductive performance, especially the first service conception rates. This study aimed to assess the effect of intrauterine therapy with ozone (IUTO...

    Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis

    June 2020 | Brazil

    To verify the influence of ozone (O3) therapy on an experimental model of rheumatoid arthritis (RA), 30 male Wistar rats were randomly allocated to 2 groups, control (C) and treatment (T), and subdivided into control (C12, C48, C72) and treatme...

    Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

    April 2020 | Italy

    Cancer

    Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity.

    Ozone at low concentrations does not affect motility and proliferation of cancer cells in vitro

    April 2020 | Italy

    Exposure to low ozone concentrations is used in medicine as an adjuvant/complementary treatment for a variety of diseases. The therapeutic potential of low ozone concentrations relies on their capability to increase the nuclear translocation of...

    Ozonated oil in wound healing: what has already been proven?

    March 2020 | Brazil

    Acute or chronic inflammatory reactions aim to control lesions, resist to pathogens attack and repair damaged tissue. The therapeutic administration of ozone known as ozone therapy appears as a possible treatment for tissue repair, as it promot...

    Topical ozone therapy restores microbiome diversity in atopic dermatitis

    March 2020 | China

    Topical ozone therapy is highly effective for treatment for AD. It can change the proportional ratio of Staphylococcus and Acinetobacter, thereby restoring the microbiological diversity in AD lesions...

    Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy - Induced Toxicity: Review and Prospects

    November 2019 | Spain

    Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy to prevent and/or treat chemotherapy-induced toxicity, and how it...

    Effects of ozonated autohemotherapy on the antioxidant capacity of Thoroughbred horses

    January 2016 | Japan

    The performance of horses undergoing regular intense exercise is adversely affected by oxidative stress. Thus, it is important to increase antioxidant production in horses in order to reduce oxidative stress. Ozonated autohemotherapy (OAHT) rep...

    The efficacy of intraarticular PRP, ozone and PRP + ozone injections in patients with osteoarthritis

    December 2019 | Turkey

    Osteoarthritis (OA) is a degenerative disease associated with the deterioration of the processes of production and destruction of cartilage and synovial tissues caused by various traumatic, biomechanical, inflammatory or genetic factors. This s...

    Effects of ozone for treating chronically refractory wounds and ulcers: A protocol for systemic review and meta-analysis of randomized clinical trials

    May 2020 | China

    The prevalence of chronically refractory wounds and ulcers is growing rapidly. However, the treatment options are not completely effective. Ozone has been demonstrated as being useful in promoting wound healing as well as adverse events in indi...

    Ozone Therapy in Periodontics: A Meta-analysis

    June 2020 | India

    A split-mouth longitudinal study was conducted to compare and evaluate the effect of ozonated water and photodynamic therapy (PDT) in nonsurgical management of chronic periodontitis, along with mechanical debridement procedure...

    An Overview of Ozone Therapy in Equine - An Emerging Healthcare Solution

    December 2016 | India

    The significance of ozone therapy has been increasingly realized in recent times particularly in equine medicine. The beneficial effects of ozone therapy are basically engendered by the mild oxidative stress it creates upon interacting with the...

    Ozone in Medicine: The Low-Dose Ozone Concept - Guidelines and Treatment Strategies

    December 2012 | Germany

    The low-dose ozone concept with its moderate oxidative stress represents an ideal hormesis strategy. Dose-response and concentration-effect relationships in the context with specific applications allow one to fix concentration ranges with thera...

    The Ozone Paradox: Ozone Is a Strong Oxidant as Well as a Medical Drug

    March 2009 | Italy

    After five decades characterized by empiricism and several pitfalls, some of the basic mechanisms of action of ozone in pulmonary toxicology and in medicine have been clarified. The present knowledge allows to understand the prolonged inhalatio...

    Prolozone™ - Regenerating Joints and Eliminating Pain

    May 2011 | United States

    Prolozone is a technique that combines the principles of neural therapy, Prolotherapy and ozone therapy. It involves the injecting combinations of procaine, anti-inflammatory medications, homeopathics, vitamins, minerals, proliferatives and ozo...

    Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

    May 2011 | Italy

    The potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological ...

    WFOT's Review on Evidence Based Ozone Therapy

    June 2015 | Italy

    We hope that this document, which is primarily intended for health practitioners using ozone who want to refine their techniques and learn about the scientific bases that support the clinical use of this therapy, would be also useful to the hea...

    Ozone therapy for dogs and cats

    May 2010 | Japan

    Ozone therapy has been reported to be effective in humans, but there was still small numbers of reports in veterinary medicine. Rectal insufflations (RI) of oxygen-ozone was effective as well as major ozone autohemotherapy (AHT), the procedure ...

    Topical ozone therapy in the treatment of pharmacodermia in a dog (canis lupus familiaris)

    2019 | Brazil

    Bacterial Infection

    Ozonated oils

    Pharmacodermia is a drug reaction that manifests itself on the skin and mucous membranes. The main drugs that cause pharmacodermia are β-lactam antibiotics. It has a rare occurrence in dogs and may present different clinical signs.

    The In Vitro Effect of Ozone Therapy Against Equine Pythium insidiosum

    2021 | Brazil

    Bacterial Infection

    Ozonated oils

    The goal of the present study was to characterize the antimicrobial action of different ozone (O3) presentations against Pythium insidiosum isolated from horses.

    Comparison of intramammary ozone administration doses in dairy cows with clinical mastitis

    2015 | Turkey

    Mastitis

    Intramammary

    Mastitis is an economically important disease leading cost associated problems. The most accurate relationship between intramammary infection and somatic cell count (SCC) can be evaluated at quarter level when SCC exceeds 100.000 cells/mL. In s...

    Intramammary application of ozone therapy to acute clinical mastitis in dairy cows

    2000 | Japan

    Mastitis

    Intramammary

    The infusion of ozone into the inflamed quarter of cows with clinical mastitis was performed and the efficacy of ozone therapy was evaluated. Ozone was infused into the inflamed quarter via a teat canal using ozone gas generating equipment. Nin...

    Ozonated oil uses in topical treatment of tick infestation in dog - Case report

    2014 | Brazil

    Protozoal Infections

    Ozonated oils

    Rhipicephalus sanguineus is a common tick in dogs. Mild skin lesions, irritation and even anemia can be caused by high infestations. A case report describes a treatment where ozonated oil was applied in dogs with tick infestation. A significant...

    Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19

    Turkey

    COVID

    Major Autohemotherapy

    Aim In this study, we aimed to investigate the effectiveness of ozone therapy, which is one of the integrative medicine applications that has been used safely for many years, on the prevalence of mortality in patients receiving COVID-19 treatme...

    Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study

    2021 | USA

    COVID

    Major Autohemotherapy

    There is still no specific treatment strategies for COVID-19 other than supportive management. DESIGN: A prospective case-control study determined by admittance to the hospital based on bed availability. PARTICIPANTS: Eighteen patients with COV...

    Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study)

    2021 | India

    COVID

    Rectal insufflation

    The Corona virus disease 19 (COVID-19) has accounted for multiple deaths and economic woes.While the entire medical fraternity and scientists are putting their best feet forward to find a solution to contain this deadly pandemic, there is a gro...

    A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial

    2021 | India

    COVID

    IV ozonated saline

    Ozone therapy has tremendous therapeutic potential owing to its antiviral, anti-inflammatory and antioxidant properties, and potential to improve oxygenation. A pilot clinical trial was conducted to evaluate the safety and efficacy ofintravenou...

    Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single centre experience

    2021 | Italy

    COVID

    Major Autohemotherapy

    The emerging outbreak of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide. We prescribed some promising medication to our patients with mild to mode...

    Comparison of ultrasound-guided local ozone (O2-O3) injection vs corticosteroid injection in the treatment of chronic plantar fasciitis: A randomized clinical trial

    2019 | Iran

    Fasciitis

    Regenerative injections

    Plantar fasciitis (PF) is one of the most common causes of heel pain. The affected area is often close to the attachment of plantar fascia to calcaneus bone. The purpose of this study was to compare the effects of ozone (O2-O3) injection to cor...

    Local ozone (O2 –o3) versus corticosteroid injection efficacy in plantar fasciitis treatment: A double-blinded rct

    2019 | Iran

    Fasciitis

    Regenerative injections

    To compare the efficacy of local ozone injection versus corticosteroid in plantar fasciopathy treatment. Patients and methods: This double-blinded randomized trial was performed on 44 adult patients with plantar fasciopathy. One group (23 patie...

    Evaluation of effect of topical ozone therapy on salivary Candidal carriage in oral candidiasis

    2015 | India

    Fungal Infections

    Topical ozonated

    Background and Aim: Ozone is highly valued for various therapeutic applications such as antimicrobial, antihypoxic, analgesic, and immunostimulating for more than a century in the medical profession. Ozone therapy is now gaining a strong footho...

    Efficacy of combination of ozonated water with oil for treatment of tinea pedis

    2018 | China

    Fungal Infections

    Topical ozonated fluid

    To evaluate efficacy of combined therapy with ozonated water and oil on patients with tinea pedis. Methods: A total of 60 patients with tinea pedis were divided into 2 groups in a randomized and blinded test. Patients in a control group were tr...

    [Ozonotherapy as an efficient component of the combined treatment of the patients presenting with bacterial vaginosis]

    2015 | Russsia

    Fungal Infections

    Vaginal insufflation

    The objective of the present study was to evaluate the effectiveness of the combined treatment of the patients suffering from bacterial vaginosis using various methods of ozone therapy. The comprehensive clinical and laboratory examination and ...

    Effect of medical ozone therapy on renal blood flow and renal function of patients with chronic severe hepatitis

    2010 | China

    Hepatitis

    Major Autohemotherapy

    Medical ozone therapy system was reported to have certain effects on the treatment of severe hepatitis, but its mechanism is not very clear. One of the causes of death of severe hepatitis is complication of renal damage or hepatorenal syndrome....

    Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C

    2011 | Egypt

    Hepatitis C

    Major Autohemotherapy

    Medical ozone is more bactericidal, fungicidal, and virucidal than any other natural substance. Some studies proved that ozone infused into donated blood samples can kill viruses 100% of the time. Ozone, because of its special biologic properti...

    Ozonetherapy in perimplant mucositis

    2010 | Italy

    Mucositis

    Subgingival ozonated fluids

    To evaluate the effectiveness of ozonetherapy as an adjunctive treatment in conventional treatment of perimplant mucositis. As a short-term and non-invasive treatment, ozonetherapy is particularly suitable for disabled patients who are reluctan...

    A comparative study for the efficacy of different forms of ozone as a treatment for alveolar osteitis

    2018 | Egypt

    Osteomyelitis

    Ozonated oils

    Dry socket is one of the most common complications following dental extraction. Although blood clot disintegration is known to be the cause of the condition, an agreement is lacking regarding the relative merits of various treatment methods. De...

    [The influence of ozone therapy to some immunological parameters in patients with generalized peritonitis]

    2012

    Peritonitis

    he immune status of the surgical treatment of 103 patients with generalized peritonitis (GP) were discussed. Patients were divided into two groups. Comparison group included 60 patients who received conventional combined therapy, main group - 4...

    Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy

    2013 | Spain

    Proctitis

    Rectal insufflation, ozonated oils

    Persistent or severe hemorrhagic radiation proctitis (HRP) has limited therapeutic options. OBJECTIVES: To describe our experience with ozone therapy (O3T) in the management of refractory HRP. METHODS: Patients (n=17; median age 69 years [range...

    [Ozone therapy and tamsulosin in the treatment of cystitis]

    2013 | Russia

    UTI

    Treatment of cystitis remains an urgent problem in urology due to its prevalence, physical and social disadaptation of patients, and not always satisfactory treatment results. The article presents the results of treatment of 40 women aged 41.5 ...

    [Transrectal ozone and magnetic therapy for treatment of chronic bacterial prostatitis]

    2019 | Russia

    UTI

    Rectal insufflation

    To evaluate the efficiency of combined transrectal ozone and magnetic therapy for the treatment of chronic bacterial prostatitis (CBP). MATERIALS AND METHODS: A total of 142 men with CBP were included in the study and allocated to different tre...

    [Topical ozone therapy: An innovative solution to patients with herpes zoster]

    2018 | China

    Viral Infection

    Ozonated oils

    o observe the clinical efficacy and safety of topical ozone therapy for patients with herpes zoster by reflectance confocal microscopy (RCM).
 Methods: A total of 60 patients with herpes zoster were divided into a control group and an ozone t...

    Ozone enema: a model of microscopic colitis in rats

    2001 | Israel

    Colitis

    Rectal insufflation

    Ozone is one of the most powerful oxidants available, with many applications in industry and medicine. Medically relevant features of ozone include bacterial and virucidal properties, disinfection, sterilization, circulatory stimulation, and di...

    Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats

    2009 | Turkey

    Colitis

    Intraperitoneal

    Necrotizing enterocolitis (NEC) remains a major cause of morbidity and death in neonates. Evidence suggests that an imbalance between activated proinflammatory response with inadequate antiinflammatory protection results in NEC. Ozone has been ...

    Medical ozone treatment ameliorates the acute distal colitis in rats

    2016 | Turkey

    Colitis

    Rectal insufflation

    To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS: Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone ...

    Biological assessment of ozone therapy on experimental oral candidiasis in immunosuppressed rats

    2018 | Egypt

    Fungal Infections

    Intraperitoneal

    Immunosuppressive drugs can compromise local or general defense mechanisms and can lead to oral candidiasis. Ozone therapy has a wide range of applications in almost every field of dentistry. Its unique properties include immunostimulant, analg...

    Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis

    2013 | Turkey

    Mediastinitis

    Intraperitoneal

    We aimed to investigate the influence of intraperitoneal ozone therapy on bacterial elimination and mediastinal inflammation in experimental Staphylococcus aureus mediastinitis. MATERIALS AND METHODS: Forty Wistar-Albino rats were randomized in...

    Preventive and curative effects of medical ozone in rats exposed to experimental osteomyelitis

    2017 | Turkey

    Osteomyelitis

    Preclinical in vivo

    Investigation of preventive and therapeutic effects of medical ozone in rats with acute osteomyelitis was aimed in this study. Staphylococcus aureus solution was injected intramedullary into right femurs of each animal to form acute osteomyelit...

    Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis

    2010 | Turkey

    Pancreatitis

    Intraperitoneal

    Our aims were to evaluate the efficacy of ozone therapy (OT) in an experimental rat model of acute necrotizing pancreatitis (ANP) and to compare its effects with hyperbaric oxygen (HBO) therapy in this entity. METHODS: Forty Sprague-Dawley rats...

    Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats

    2010 | Brazil

    Peritonitis

    Intraperitoneal

    The antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial. Objectives: To evaluate the effect of intraperitoneal (i.p.) O3...

    Effect of Ozone Therapy (OT) on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

    2014 | Turkey

    Peritonitis

    Intraperitoneal

    Ozone is a three-oxygen molecule (O3). Ozone therapy (OT) is systematically effective when pathological inflammatory and immunologic processes are activated. Among of these conditions are wound healing, macular degeneration related to aging, an...

    Effects of antibiotic and intra-peritoneal ozone administration on proinflammatory cytokine formation, antioxidant levels and abdominal organ functions in the treatment of experimentally generated infectious peritonitis in rabbits

    2019 | Turkey

    Peritonitis

    Intraperitoneal

    In this study we investigated the effects of antibiotic and intraperitoneal ozone administration on proinflammatory cytokine, antioxidant levels and tissue damage in the treatment of experimentally infectious peritonitis. Thirty-three adult mal...

    Effects of Ozonated Olive Oil on Acute Radiation Proctitis in Rats

    2013 | Turkey

    Proctitis

    Rectal insufflation

    Acute radiation proctitis is a common complication of pelvic radiation and management of acute radiation proctitis is under evaluation. The beneficial effects of ozonated olive oil (OzOO) have already been shown in the treatment of chronic woun...

    Aqueous ozone therapy improves the standard treatment of leishmaniasis lesions in animals leading to local and systemic alterations

    2020 | Brazil

    Protozoal infections

    Ozonated fluids

    The current treatment of leishmaniasis presents some problems, such as cell toxicity, parenteral route, and time of treatment. Ozone emerges as an option to accelerate the standard treatment due to the immunomodulatory, antioxidant, and wound h...

    Efficacy of medical ozone in attenuation of murine Schistosomiasis mansoni infection morbidity

    2007 | Egypt

    Protozoal infections

    Intraperitoneal

    Mice were divided into 3 groups: non-infected control, S. mansoni infected non-treated for 10 weeks and group receiving ozone intraperitoneally for 21 days 10 weeks postinfection. Results showed that ozone therapy in chronic schistosomiasis man...

    Effect of ozone pre-conditioning on redox activity in a rat model of septic shock

    2010 | Cuba

    Septic shock

    Intraperitoneal

    The confirmed advantageous effects of oxygen/ozone therapy in several clinical conditions stimulated experimental studies on effects of the therapy in induced septic shock. This study researches the influence of Ozone Oxidative Pre-conditioning...

    Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

    2020 | Turkey

    Septic shock

    Intraperitoneal

    Purpose This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods Rats were divided into 5 groups. Then s...

    Effects of ozone oxidative preconditioning on different hepatic biomarkers of oxidative stress in endotoxic shock in mice

    2011 | Germany

    Septic shock

    Intraperitoneal

    In endotoxic shock, variations are known to occur in different biochemical parameters of oxidative stress. Ozone oxidative preconditioning (OOP) is a good candidate to restore the redox balance on different tissue. This investigation examined t...

    Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats

    2016 | China

    UTI

    Intraperitoneal

    Tubulointerstitium inflammation is a common pathway aggravating chronic kidney disease (CKD) progression and the mechanism is partly associated with excessive activation of toll-like receptor 4 (TLR4) in tubulointerstitium. Ozone therapy is dem...

    Ozone therapy ameliorates inflammation and endometrial injury in rats with pelvic inflammatory disease

    2018 | China

    UTI

    Rectal insufflation

    As a common cause of infertility, pelvic inflammatory disease (PID) is characterized by chronic pain, ectopic pregnancy as well as inflammation and infection of the female upper genital tract. Ozone water, also known as O(3,) has been previousl...

    Ozone therapy in conjunction with oral antibiotics as a successful primary and sole treatment for chronic septic prosthetic joint: review and case report

    2018 | USA

    Arthritis

    Regenerative injections

    The world is facing crisis in management of infectious diseases. The mainstay of treatment has been chemical anti-infectives. These drugs are failing, as superbugs emerge and medicine becomes more sophisticated with treatments such as prostheti...

    Ozone therapy as a primary and sole treatment for acute bacterial infection: Case report

    2018 | USA

    Bacterial infection

    Major Autohemotherapy

    The world is facing a crisis of antibiotic resistance, which impacts every treating physician on the planet. Thousands of patients die yearly in the USA from infections that have failed to respond to anti-infectives. Alarms have been ringing ab...

    The antibacterial effect of topical ozone on the treatment of MRSA skin infection

    2018 | China

    Bacterial infection

    Ozonated oils

    Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staph...

    Severe Spinal Surgery Infection and Local Ozone Therapy as Complementary Treatment: A Case Report

    2019 | Italy

    CNS infections

    Subcutaneous ozonated fluids

    Infection is a serious surgical complication that significantly increases morbidity and mortality rates as well as health care expenses. Increased bacterial resistance to antibiotics makes the treatment of such events even more troublesome. OBJ...

    Compassionate Use of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: a Case-Control Study

    2021 | Spain

    COVID

    Rectal insufflation

    To evaluate effect of rectal ozone in severe COVID-19 pneumonia and to compare it to standard of care (SOC). MATERIAL AND METHODS: In a case-control study, 14 patients with severe bilateral COVID-19 pneumonia (positive RT-PCR), treated with SOC...

    Ozone Treatment Unveils the Veil of Candida parapsilosis Infection in the Knee Joint: A Case Report and Literature Review

    2020 | China

    Fungal infections

    Subcutaneous ozonated fluids

    Candida infection is common, while Candida parapsilosis infection in the knee joint is rare. Local symptoms of Candida infections in the knee are atypical, rarely associated with systemic symptoms, and difficult to distinguish from other types ...

    Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with ozone therapy

    2016 | Sierra Leone

    Viral infections

    Major Autohemotherapy

    Ebola Virus Disease (EVD) has ravaged three countries in West Africa. The mortality rate is extremely high, and it is perceived not only as threat to all of Africa but to the entire world. There is no known treatment to date other than administ...

    Activity of ozonated water and ozone against Staphylococcus aureus and Pseudomonas aeruginosa biofilms

    2011 | poland

    Bacterial infection

    Ozonated fluids

    The known bactericidal properties of ozone have not been checked in relation to its action on bacterial biofilms. This is especially true of ozonated fluids. The aim of this study was to investigate the bactericidal activity of ozonated water a...

    Effect of low-dose gaseous ozone on pathogenic bacteria

    2012 | Brazil

    Bacterial infection

    Ozonated fluids

    Treatment of chronically infected wounds is a challenge, and bacterial environmental contamination is a growing issue in infection control. Ozone may have a role in these situations. The objective of this study was to determine whether a low do...

    Effects of ozone and ultraviolet radiation treatments on the infectivity of Toxoplasma gondii oocysts

    2008 | France

    Protozoal infections

    Clinical toxoplasmosis in humans has been epidemiologically linked to the consumption of drinking water contaminated by Toxoplasma gondii oocysts. We evaluated killing of T. gondii oocysts after ultraviolet (UV) or ozone treatments by bioassay ...

    Giardia duodenalis: Effects of an ozonized sunflower oil product (Oleozon®) on in vitro trophozoites

    2009 | Cuba

    Protozoal infections

    Ozonated oils

    The ozonized sunflower oil product (Oleozon®) was investigated to explore its cytotoxic activity on Giardia duodenalis in vitro cultivated trophozites. Oleozon® produced inactivation of Giardia trophozoites in a dose- and cell density-depende...

    The High Potential of Ozone Gas to Inactivate Echinococcus granulosus Protoscoleces During Hydatid Cyst Surgery

    2020 | Iran

    Protozoal infections

    Ozonated fluids

    In medicine, ozone therapy is effectively used in a broad spectrum of diseases. Reviews have shown that ozone gas demonstrates potent antimicrobial effects against a wide range of pathogenic microorganisms, such as oral bacteria, fungi, viruses...

    The effect of ozone therapy on the activity of the autonomic nervous system

    2012 | Russia

    CNS

    Various

    We studied 48 patients, mean age 57 years, 14 men, 34 women, with chronic cerebrovascular disease and autonomic dysfunction. Patients had different types of autonomic response (sympathicotonic or normotonic). Autonomic tone at baseline, autonom...

    Ozone therapy as a complementary treatment in cardiovascular diseases

    2017 | Italy

    CVS

    Various

    Ozone is a metastable gas, made up of three oxygen atoms, faintly blue, which owes its name to the characteristic pungent odor (from the Greek ozein: smell). Ozone was used for therapeutic purposes since the end of eighteenth century. The curre...

    A critical evaluation of the use of ozone and its derivatives in dentistry

    2020 | Italy

    Dentistry

    Various

    OBJECTIVE: The therapeutic application of ozone and its derivatives in the dental field has been used for many purposes. However, there has yet to be a consistent evaluation of the outcomes, due to the lack of standardization of the treatment o...

    Ozone therapy in dentistry. A brief review for physicians

    2014 | USA

    Dentistry

    Various

    The 21(st) century dental practice is quite dynamic. New treatment protocols and new materials are being developed at a rapid pace. Ozone dental therapy falls into the category of new treatment protocols in dentistry, yet ozone is not new at al...

    Ozone therapy in dentistry: A strategic review

    2011 | India

    Dentistry

    Various

    THE ORAL CAVITY APPEARS AS AN OPEN ECOSYSTEM, WITH A DYNAMIC BALANCE BETWEEN THE ENTRANCE OF MICROORGANISMS, COLONIZATION MODALITIES, AND HOST DEFENSES AIMED TO THEIR REMOVAL: To avoid elimination, bacteria need to adhere to either hard dental ...

    Role of ozone therapy in minimal intervention dentistry and endodontics - a review

    2013 | India

    Dentistry

    Various

    Ozone has been successfully used in medical field since many years owing to its oxidizing property making it an excellent antimicrobial agent. Moreover its potent anti-inflammatory property along with favorable cellular and humoral immune respo...

    Ozone and ozonated oils in skin diseases: a review

    2010 | Italy

    Dermatological

    Ozonated oils

    Although orthodox medicine has provided a variety of topical anti-infective agents, some of them have become scarcely effective owing to antibiotic- and chemotherapeutic-resistant pathogens. For more than a century, ozone has been known to be a...

    Emerging roles of ozone in skin diseases

    2018 | USA

    Dermatological

    Various

    Ozone was discovered in the mid-nineteenth century and is proven to have many therapeutic effects, including its common application as a disinfectant to kill microorganisms in various conditions. Ozone therapies have been utilized for various p...

    An Overview of Ozone Therapy in Equine- an Emerging Healthcare Solution

    2016 | India

    General

    Various

    The significance of ozone therapy has been increasingly realised in recent times particularly in equine medicine. The beneficial effects of ozone therapy are basically engendered by the mild oxidative stress it creates upon interacting with the...

    Application of ozone therapy in interventional medicine

    2019 | China

    General

    Various

    Ozone therapy has been gradually accepted by doctors in various fields because it has been safe, convenient, and inexpensive since the twentieth century. It has been used in the treatment of various diseases with satisfactory results, especiall...

    Application of ozone therapy in surgical practice

    2018 | Ukraine

    General

    Various

    Summarizing the review of literary sources, one can conclude that, despite a significant number of scientific papers devoted to the problem of pyoinflammatory complications of diabetes, there remain issues that require further study and solutio...

    Oxygen-Ozone Therapy in Proctology

    1990 | Germany

    General

    Various

    The diffusion of oxygen through the colon wall could be demonstrated in animal experiment. The relevant rise in PaO2 can be evidenced both in blood vessels and in the liver, whereby a significantly high increase of 250% above the normal value w...

    Ozone in Medicine: The Low-Dose Ozone Concept-Guidelines and Treatment Strategies

    2012 | Cuba

    General

    Various

    The low-dose ozone concept with its moderate oxidative stress represents an ideal hormesis strategy. Dose-response and concentration-effect relationships in the context with specific applications allow one to fix concentration ranges with thera...

    Modulator effect of ozone therapy over immune system activity

    2013 | Cuba

    Immune system

    Various

    The employment of biological medicine has allowed the application of beneficial and systemic therapies where the body is treated as a whole. The ozone therapy is a modality of the biological medicine, it is a natural therapeutical procedure tha...

    [Ozone therapy in rheumatic diseases: a systematic review]

    2006 | Spain

    MSK

    Various

    OBJECTIVE: To perform a systematic review to analyze the efficacy on which the use of ozone therapy in musculoskeletal diseases is based. METHODS: A literature search was performed in PubMed, Embase and the Cochrane Library using highly sensiti...

    Effectiveness of Ozone Injection Therapy in Temporomandibular Disorders

    2020 | Iran

    MSK

    Various

    Temporomandibular disorder is a multifactorial disease that causes pain in the jaw and face area with nondental origin, which frequently limits talking, chewing, and other jaw activities. Various factors such as malocclusion, trauma, stress, pa...

    Clinical utility of ozone therapy for musculoskeletal disorders

    2018 | USA

    MSK

    Various

    Oxygen-ozone (O(3)) therapy serves as an alternative medical technique that increases the oxygen in the body along with the introduction of O(3). O(3) therapy has finally reached a level where the biological mechanisms of action have been under...

    Ozone therapy in obstetrics and gynecology: Achievements and prospects

    2019 | Russia

    Obs/Gyne

    Various

    The paper presents a systems analysis of the data available in the current literature on the use of ozone therapy in obstetric and gynecological practice and its benefits. It considers data on the possibilities of using medical ozone in gynecol...

    Clinical utility of ozone therapy for musculoskeletal disorders

    2018 | USA

    MSK

    Various

    Oxygen-ozone (O(3)) therapy serves as an alternative medical technique that increases the oxygen in the body along with the introduction of O(3). O(3) therapy has finally reached a level where the biological mechanisms of action have been under...

    Ozone therapy in obstetrics and gynecology: Achievements and prospects

    2019 | Russia

    Obs/Gyne

    Various

    The paper presents a systems analysis of the data available in the current literature on the use of ozone therapy in obstetric and gynecological practice and its benefits. It considers data on the possibilities of using medical ozone in gynecol...

    Ozone therapy in urology

    2013 | Mexico

    Renal

    Various

    The application of ozone in the most frequent pathologies of Urology has had an astonishing result such as in Prostatic hyperplasia, prostate cancer, Balanitis, stricture of urethra, erectile dysfunction, ejaculation Peyronie disease, interstit...

    Ozone therapy in veterinary medicine: A review

    2020 | Italy

    Veterinary

    Various

    Ozone (O(3)) is a triatomic form of oxygen. As O(3) rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O(3)/O(2) is used in medicine. ATP is widely available for cellular activity. O...

    The main uses of ozone therapy in diseases of large animals: A review

    2021 | Brazil

    Veterinary

    Various

    Ozone (O(3)) is a molecule composed of three oxygen atoms, highly unstable, capable of reacting with various substances of the human and animal organism, giving rise to by-products that will participate in biochemical reactions. Thus, O(3) has ...

    The Use of Ozone Therapy in Veterinary Medicine: A Systematic Review

    2020 | Romania

    Veterinary

    Various

    In the past decades, veterinary medicine has endorsed more alternative medicine practices, among which ozone therapy. Ozone therapy is a therapeutic method associated with integrative medicine by which ozone is administered to an organism in or...

    Use of ozone in medicine and veterinary practice

    2019 | Poland

    Veterinary

    Various

    Ozone is a triatomic allotrope of oxygen that can be produced in specially designed machines: ozone generators (ozonators). It breaks down to dioxygen (O-2) and active atomic oxygen (O), which is a very strong oxidant. Due to the fact that its ...

    Medical ozone and its use in veterinary surgery

    2011 | Turkey

    Veterinary

    Various

    Ozone is a molecule consisting of three oxygen atoms, formed as a result of oxygen being exposed to high-energy electric current and ultraviolet rays in nature. It is a powerful oxidising agent. Therefore, it has bactericidal, virucidal and fun...

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